Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215964 | 0.86 | MAPK14 (0.75) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7221787 | 0.84 | MAPK13 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215967 | 0.83 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215094 | 0.81 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215839 | 0.74 | MAPK14 (0.69) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL13738144 | 0.74 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7221013 | 0.72 | MAPK14 (0.53) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrazine SCHEMBL7215381 | 0.71 | MAPK14 (0.50) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7221781 | 0.70 | MAPK14 (0.86) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL14523454 | 0.68 | CNR1 (0.60) | CKS1BSKP1SKP2SYKSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |