Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.75 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.75 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.75 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.70 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215965 | 0.86 | MAPK13 (0.55) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL7221781 | 0.85 | MAPK14 (0.86) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL7215092 | 0.82 | MAPK14 (0.98) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215967 | 0.81 | MAPK13 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215445 | 0.77 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215450 | 0.77 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221086 | 0.77 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7221081 | 0.77 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7217284 | 0.77 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7217289 | 0.77 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |