Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL3871268 | 1.00 | THRB (0.53) | THRBTSHRALDH1A1EGLN1LMNA | |
| Adipic Acid SCHEMBL3877653 | 0.92 | THRB (0.50) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Glutarate SCHEMBL3866346 | 0.92 | THRB (0.50) | THRBTSHRALDH1A1EGLN1HSD17B10 | |
| SCHEMBL7090019 | 0.90 | THRB (0.58) | THRBTSHRALDH1A1EGLN1LMNA | |
| Bicarbonate SCHEMBL10996730 | 0.89 | THRB (0.59) | THRBTSHRALDH1A1EGLN1LMNA | |
| Acetic Acid SCHEMBL28298395 | 0.89 | THRB (0.59) | THRBTSHRALDH1A1EGLN1LMNA | |
| SCHEMBL19409375 | 0.89 | THRB (0.64) | THRBTSHRALDH1A1EGLN1LMNA | |
| SCHEMBL15030 | 0.89 | — | — | |
| Mercaptopropionic Acid SCHEMBL9182736 | 0.88 | THRB (0.47) | THRBTSHRALDH1A1EGLN1LMNA | |
| Malonic Acid SCHEMBL3868425 | 0.87 | THRB (0.53) | THRBTSHRALDH1A1EGLN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185287-A1 | Modified epoxy resin, process for its production, photosensitive resin composition and photsensitive element | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2007-08-09 | — | — | US | claimed |
| EP-2853253-B1 | Dental curable composition containing particles with different refractive indexes | SHOFU INC (JP) | 2022-04-27 | — | — | EP | disclosed |
| US-20210189182-A1 | ADHESIVE FILM AND LAMINATE FILM INCLUDING THE SAME | INNOX ADVANCED MATERIALS CO., LTD. (KR) | 2021-06-24 | — | — | US | disclosed |
| US-20200253835-A1 | Dental Curable Composition | TOKUYAMA DENTAL CORPORATION (JP) | 2020-08-13 | — | — | US | disclosed |
| EP-3682862-A1 | CURABLE DENTAL COMPOSITION | Tokuyama Dental Corporation (JP) | 2020-07-22 | — | — | EP | disclosed |
| EP-1704845-B1 | Polymerization initiator composition for dental or surgical adhesive compositions | SUN MEDICAL CO LTD (JP) | 2019-07-03 | — | — | EP | disclosed |
| EP-2902007-B1 | DENTAL FILLING REPAIRING MATERIAL | TOKUYAMA DENTAL CORP (JP) | 2019-01-09 | — | — | EP | disclosed |
| US-9511005-B2 | Dental curable composition containing particles with different refractive indexes | SHOFU INC. (JP) | 2016-12-06 | — | — | US | disclosed |
| US-9345646-B2 | Dental visible-light curable composition and method of identifying presence of same | SHOFU INC. (JP) | 2016-05-24 | — | — | US | disclosed |
| US-9192693-B2 | Method for treatment of emphysema | TERUMO KABUSHIKI KAISHA (JP) | 2015-11-24 | — | — | US | disclosed |
| EP-0672950-B1 | WATERLESS LITHOGRAPHIC PLATE | TORAY INDUSTRIES (JP) | 1999-11-24 | — | — | EP | disclosed |
| EP-0952198-A1 | Precoating type adhesive composition | THREE BOND CO., LTD. (JP) | 1999-10-27 | — | — | EP | disclosed |
| EP-0616017-B1 | Ink, ink-jet recording process making use of the ink, and apparatus using the ink | CANON KK (JP) | 1999-08-18 | — | — | EP | disclosed |
| US-5866294-A | HIGH DURABLE PRINTING | TORAY INDUSTRIES, INC. (JP) | 1999-02-02 | — | — | US | disclosed |
| US-5811210-A | PHOTOSENSITIVE LAYER AND SILICONE RUBBER LAYER LAMINATED IN ORDER ONTO A SUBSTRATE; PEEL BONDING STRENGTH AND ELASTIC MODULUS; FOR WEB OFFSET AND NEWSPAPER OFFSET PRINTING DURABILITY | TORAY INDUSTRIES, INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| CN-1178546-A | Curable resin composition for water-based paints | DAINIPPON INK & CHEMICALS (JP) | 1998-04-08 | — | — | CN | disclosed |
| US-5696182-A | AQUEOUS MIXTURES CONTAINING WATER SOLUBLE ORGANIC SOLVENT, COLORING MATERIALS, WATER SOLUBLE ACRYLATED POLYOL OLIGOMER OR POLYETHER OR POLYURETHANE CONTAINING BOTH HYDROPHOBIC AND HYDROPHILIC DIOLS | CANON KABUSHIKI KAISHA (JP) | 1997-12-09 | — | — | US | disclosed |
| EP-0802067-A1 | DIRECT DRAWING TYPE WATERLESS PLANOGRAPHIC ORIGINAL FORM PLATE | TORAY INDUSTRIES, INC. (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0678785-A1 | DRY LITHOGRAPHIC FORME | TORAY INDUSTRIES, INC. (JP) | 1995-10-25 | — | — | EP | disclosed |
| EP-0672950-A1 | WATERLESS LITHOGRAPHIC PLATE | TORAY INDUSTRIES, INC. (JP) | 1995-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253835-A1 | Dental Curable Composition | SP1, H1-0, ERH | THRB 1005/4885TSHR 2813/4885ALDH1A1 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.