Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.80 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.80 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | MMP3 | P08254 | 11/20 | 0.56 |
| ▸ | MMP7 | P09237 | 8/20 | 0.56 |
| ▸ | MMP13 | P45452 | 8/20 | 0.56 |
| ▸ | MMP9 | P14780 | 6/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526779 | 0.89 | MMP1 (0.64) | MMP1ADAM17PKMMMP2 | |
| SCHEMBL6523181 | 0.89 | MMP1 (0.64) | MMP1ADAM17PKMMMP2 | |
| SCHEMBL8216398 | 0.89 | MMP1 (0.64) | MMP1ADAM17PKMMMP2 | |
| SCHEMBL7221169 | 0.87 | MMP1 (0.74) | MMP1ADAM17PKMMMP3MMP7 | |
| SCHEMBL6229896 | 0.84 | MMP1 (0.69) | MMP1ADAM17PKMMMP3MMP7 | |
| SCHEMBL7220742 | 0.82 | MMP1 (0.69) | MMP1ADAM17PKMMMP3MMP7 | |
| SCHEMBL7805720 | 0.82 | CA12 (0.57) | MMP1ADAM17MMP3MMP7MMP13 | |
| SCHEMBL2705860 | 0.81 | MMP1 (0.67) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL2705855 | 0.81 | MMP1 (0.67) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL2706480 | 0.81 | MMP1 (0.67) | MMP1MMP3MMP7MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |