Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.69 |
| ▸ | MMP3 | P08254 | 11/20 | 0.55 |
| ▸ | MMP9 | P14780 | 8/20 | 0.55 |
| ▸ | MMP7 | P09237 | 8/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 7/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214256 | 0.94 | MMP1 (0.60) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7220828 | 0.85 | MMP1 (0.55) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7220826 | 0.85 | MMP1 (0.55) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7216567 | 0.82 | MMP1 (0.80) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7058353 | 0.81 | MMP1 (0.69) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL5539183 | 0.80 | MMP1 (0.50) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7221238 | 0.79 | ADAM17 (0.57) | MMP1ADAM17MMP3MMP2MMP8 | |
| SCHEMBL7245645 | 0.77 | MMP1 (0.51) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7221169 | 0.77 | MMP1 (0.74) | MMP1ADAM17MMP3MMP9MMP7 | |
| SCHEMBL7428159 | 0.76 | MMP1 (0.80) | MMP1MMP3MMP9MMP7MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |