Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804276 | 0.84 | MAPT (0.57) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL2804412 | 0.84 | MAPT (0.57) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL2807422 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL9581504 | 0.79 | KDM4E (0.60) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL3931733 | 0.78 | KDM4E (0.69) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL11753068 | 0.76 | KDM4E (0.43) | ALDH1A1KDM4ETHRBHPGDKMT2A | |
| SCHEMBL1586810 | 0.73 | KDM4E (1.00) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL17203149 | 0.71 | KDM4E (0.58) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL2810908 | 0.71 | KDM4E (0.58) | ALDH1A1KDM4ETHRBHPGDAPEX1 | |
| SCHEMBL25811506 | 0.71 | KDM4E (0.67) | ALDH1A1KDM4ETHRBHPGDAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509475-B1 | Friedel-Crafts acylation catalyzed by Lewis acid alkylaluminum dichloride; chemical reduction, salt formation | MERCK PATENT GMBH (DE) | 2003-01-21 | — | — | US | disclosed |