Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931733 | 0.80 | KDM4E (0.69) | KDM4EALDH1A1HPGDTHRBPTPN5 | |
| SCHEMBL17203149 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1HPGDTHRBPTPN5 | |
| SCHEMBL2807422 | 0.78 | KDM4E (0.55) | KDM4EALDH1A1HPGDTHRBHSD17B10 | |
| SCHEMBL17205786 | 0.77 | RAB9A (0.59) | KDM4EALDH1A1HPGDTHRBHSD17B10 | |
| SCHEMBL5881930 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10NR4A2 | |
| SCHEMBL18941101 | 0.77 | HCRTR1 (0.73) | KDM4EALDH1A1HPGDTHRBHSD17B10 | |
| SCHEMBL13726361 | 0.76 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDTHRBNR4A2 | |
| SCHEMBL2804276 | 0.76 | MAPT (0.57) | KDM4EALDH1A1HPGDTHRBHSD17B10 | |
| SCHEMBL2804412 | 0.76 | MAPT (0.57) | KDM4EALDH1A1HPGDTHRBHSD17B10 | |
| SCHEMBL2981080 | 0.75 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDTHRBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240718-A1 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVE, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | WESTFALISCHE WILHELMS UNIVERSITÄT MÜNSTER (DE) | 2010-09-23 | — | — | US | disclosed |
| EP-2215059-A2 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVE, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | Westfälische Wilhelms-Universität Münster (DE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009040314-A2 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | Westfälische Wilhelms Universität Münster (DE) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240718-A1 | NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVE, SUITABLE FOR INHIBITING PHOSPHOLIPASE A2 | PLD2, PLA2G1B, PLA2G4A | KDM4E 2977/4885ALDH1A1 791/4885HPGD 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.