Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.59 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297914 | 1.00 | CTSS (0.59) | CTSSCTSKKLK5CYP3A4REN | |
| SCHEMBL25075938 | 0.87 | CTSS (0.61) | CTSSCTSKKLK5CYP3A4CTNNB1 | |
| SCHEMBL28133826 | 0.85 | CTSS (0.62) | CTSSCTSKCYP3A4APPCTNNB1 | |
| SCHEMBL9815894 | 0.82 | KLK5 (0.71) | CTSSCTSKKLK5RENAPP | |
| SCHEMBL8787243 | 0.82 | KLK5 (0.71) | CTSSCTSKKLK5RENAPP | |
| SCHEMBL9832414 | 0.82 | KLK5 (0.71) | CTSSCTSKKLK5RENAPP | |
| SCHEMBL6873021 | 0.82 | KLK5 (0.71) | CTSSCTSKKLK5RENAPP | |
| SCHEMBL7356467 | 0.82 | CTSL (0.61) | CTSSCTSKREN | |
| SCHEMBL4600435 | 0.81 | CTSS (0.76) | CTSSCTSKCYP3A4 | |
| SCHEMBL4122289 | 0.81 | CTSS (0.76) | CTSSCTSKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617317-B1 | Reducing the rate of degradation of proteins in an animal | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-09 | — | — | US | disclosed |