Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.97 |
| ▸ | PDE4A | P27815 | 9/20 | 0.97 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.97 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.97 |
| ▸ | ADORA2B | P29275 | 14/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380135 | 0.98 | ADORA2A (1.00) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27396492 | 0.98 | ADORA2A (1.00) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4423680 | 0.86 | ADORA2B (1.00) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6233166 | 0.83 | ADORA2B (1.00) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27395394 | 0.83 | ADORA2B (1.00) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5515444 | 0.82 | ADORA2A (0.71) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27586849 | 0.82 | ADORA2A (0.71) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7455767 | 0.82 | ADORA2A (0.71) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1892011 | 0.82 | ADORA2B (0.92) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL60158 | 0.81 | ADORA2A (0.70) | ADORA2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |