SCHEMBL60158

SCHEMBL60158

CC(C)Cn1c(=O)[nH]c2nc[nH]c2c1=O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 9/20 0.70
PDE4A P27815 6/20 0.70
PDE4B Q07343 6/20 0.70
PDE4C Q08493 6/20 0.70
PDE4D Q08499 6/20 0.70
ADORA2B P29275 12/20 0.67
ADORA3 P0DMS8 8/20 0.67
CFTR P13569 2/20 0.56
PDE2A O00408 2/20 0.52
PDE1A P54750 2/20 0.52
PDE1B Q01064 2/20 0.52
PDE1C Q14123 2/20 0.52
ADORA1 P30542 2/20 0.52
PDE3A Q14432 2/20 0.52
PDE5A O76074 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
MAPK1 P28482 1/20 0.52
SCN1A P35498 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7326960 0.88 ADORA2A (0.67) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL59949 0.85 ADORA2B (0.72) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL27396492 0.83 ADORA2A (1.00) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL380135 0.83 ADORA2A (1.00) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL7217322 0.81 ADORA2A (0.97) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL4014471 0.80 ADORA2A (0.63) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL4423680 0.80 ADORA2B (1.00) ADORA2APDE4APDE4BPDE4CPDE4D
Phosphoric Acid SCHEMBL8500178 0.80 ADORA2B (0.64) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL9432917 0.80 ADORA2A (0.55) ADORA2APDE4APDE4BPDE4CPDE4D
SCHEMBL27586849 0.80 ADORA2A (0.71) ADORA2APDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 219 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2446024-A1 MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR Life&Light Limited (GB) 2012-05-02 EP claimed
US-20100330047-A1 Mesenchymal Stem Cells Grown Under Hypoxic Conditions: Compositions, Methods and Uses Therefor LIFE & LIGHT LTD. (GB) 2010-12-30 US claimed
WO-2010150094-A1 MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR LIFE & LIGHT LIMITED (GB) 2010-12-29 WO claimed
WO-2010108008-A2 BSC CELL DIFFERENTIATION AND USE IN THERAPY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) 2010-09-23 WO claimed
CN-1134537-C Separation, extracorporeal culture, preparation and application of human primitive mesenchymal stem cell population 四川轻化工学院 2004-01-14 CN claimed
CN-1287166-A Separation, extracorporeal culture, preparation and application of human primitive mesenchymal stem cell population HE QINGHUA (CN) 2001-03-14 CN claimed
US-12173323-B2 Methods of using PDX1-positive pancreatic endoderm cells and endocrine precursor cells VIACYTE, INC. (US) 2024-12-24 US disclosed
US-20240409900-A1 CELL ENCAPSULATION DEVICE COMPRISING A PANCREATIC PROGENITOR CELL POPULATION VIACYTE, INC. (US) 2024-12-12 US disclosed
US-20240220740-A1 AUTOMATIC CONSTRUCTION METHOD FOR PARALLEL CORPORA AND INFORMATION PROCESSING APPARATUS FUJITSU LIMITED (JP) 2024-07-04 US disclosed
EP-4394648-A1 PARALLEL CORPUS CONSTRUCTION PROGRAM, PARALLEL CORPUS CONSTRUCTION METHOD, AND INFORMATION PROCESSING APPARATUS FUJITSU LIMITED (JP) 2024-07-03 EP disclosed
CN-111867634-B Enhancement of translocation of micro/nanoparticles across mucus layers using alginate oligomers 阿尔吉法玛公司 2024-06-11 CN disclosed
US-11905530-B2 Cell encapsulation device comprising a pancreatic progenitor cell population VIACYTE, INC. (US) 2024-02-20 US disclosed
US-11896622-B2 Methods of producing pancreatic hormones VIACYTE, INC. (US) 2024-02-13 US disclosed
CN-1287166-A Separation, extracorporeal culture, preparation and application of human primitive mesenchymal stem cell population HE QINGHUA (CN) 2001-03-14 CN disclosed
CN-1206420-A Novel A1 adenosine receptor agonists and antagonists UNIV FLORIDA (US) 1999-01-27 CN disclosed
CN-1182432-A Human neuropeptide receptor HUMAN GENOME SCIENCES INC (US) 1998-05-20 CN disclosed
US-5480999-A CONTAINING AN ACID AND AN ARGININE ANALOGUE SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1996-01-02 US disclosed
US-5360925-A Cardio cerebrovascular disorders, antiinflammatory agents and immune disorders SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) 1994-11-01 US disclosed
EP-0116938-A1 Benzoheterocyclic carbamates USV PHARMACEUTICAL CORPORATION (US) 1984-08-29 EP disclosed
US-4456687-A CULTURES; CYCLIC ADENOSINE-3'-PHOSPHATE STIMULANTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1984-06-26 US disclosed