Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.84 |
| ▸ | MMP9 | P14780 | 6/20 | 0.84 |
| ▸ | MMP8 | P22894 | 6/20 | 0.84 |
| ▸ | MMP3 | P08254 | 6/20 | 0.84 |
| ▸ | MMP1 | P03956 | 5/20 | 0.84 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074930 | 0.92 | MMP2 (1.00) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7077478 | 0.91 | MMP2 (0.71) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7221722 | 0.86 | MMP2 (0.76) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7221720 | 0.85 | MMP2 (0.61) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL27517321 | 0.84 | MMP2 (0.81) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7075141 | 0.84 | MMP2 (0.80) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7075248 | 0.84 | MMP2 (0.76) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7076033 | 0.83 | MMP2 (0.80) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7985039 | 0.82 | MMP1 (0.56) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL7078224 | 0.82 | MMP2 (0.77) | MMP2MMP9MMP8MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |
| US-6118001-A | ANTICANCER AGENT; ANTIARTHRITIC AGENT | DARWIN DISCOVERY, LTD. (GB) | 2000-09-12 | — | — | US | disclosed |
| EP-0968182-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998005635-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1998-02-12 | — | — | WO | disclosed |