Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.72 |
| ▸ | RARB | P10826 | 5/20 | 0.55 |
| ▸ | RARG | P13631 | 5/20 | 0.55 |
| ▸ | RXRB | P28702 | 5/20 | 0.55 |
| ▸ | RXRG | P48443 | 5/20 | 0.55 |
| ▸ | RARA | P10276 | 4/20 | 0.55 |
| ▸ | HNF4A | P41235 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872423 | 0.87 | RXRA (0.61) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL29395963 | 0.87 | RXRA (0.61) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL5540284 | 0.85 | RXRA (0.80) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL1072441 | 0.85 | RXRA (1.00) | RXRARARBRARGRXRBRXRG | |
| Acetic Acid SCHEMBL5879410 | 0.84 | RXRA (0.62) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7950320 | 0.83 | RXRA (0.57) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7946771 | 0.78 | RXRA (0.52) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL697774 | 0.77 | RXRA (0.50) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8014224 | 0.77 | RXRA (0.50) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7218238 | 0.77 | RXRA (0.73) | RXRARARBRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5475113-A | Treatment of skin disorders, skin cancer | ALLERGAN, INC. (US) | 1995-12-12 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |