Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262378 | 0.90 | NPC1 (0.56) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10865547 | 0.87 | MGLL (0.51) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14660779 | 0.87 | MGLL (0.51) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6665979 | 0.87 | LOXL2 (0.66) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1627925 | 0.86 | CYP4A11 (0.60) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2412752 | 0.86 | LOXL2 (0.59) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20963807 | 0.83 | CYP4A11 (0.66) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18105886 | 0.83 | CYP4A11 (0.57) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18105885 | 0.83 | CYP4A11 (0.57) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5606050 | 0.83 | TSHR (0.51) | LOXL2MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627651-B1 | Exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group and inhibitors of HIV (human | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| EP-1182195-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |