Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 8/20 | 0.37 |
| ▸ | NOS3 | P29474 | 5/20 | 0.37 |
| ▸ | NOS2 | P35228 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218366 | 0.80 | NPC1 (0.33) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7218361 | 0.80 | NPC1 (0.33) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28044670 | 0.75 | GSR (0.43) | KMT2ANPC1RAB9A | |
| SCHEMBL28612372 | 0.67 | NPC1 (0.46) | KMT2ANPC1RAB9AGLA | |
| SCHEMBL11599997 | 0.67 | NPC1 (0.46) | KMT2ANPC1RAB9AGLA | |
| Hydrochloric Acid SCHEMBL17275456 | 0.65 | NPC1 (0.45) | KMT2ANPC1RAB9AGLA | |
| Hydrochloric Acid SCHEMBL17275457 | 0.65 | NPC1 (0.45) | KMT2ANPC1RAB9AGLA | |
| SCHEMBL10615777 | 0.65 | CA2 (0.43) | CYP2C19MEN1KMT2ACYP1A2TSHR | |
| SCHEMBL10617270 | 0.64 | NPC1 (0.41) | CYP2C19KMT2ACYP1A2TSHRCYP3A4 | |
| SCHEMBL6666888 | 0.63 | NPC1 (0.49) | KMT2ANPC1RAB9AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | claimed |
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |