Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218361 | 1.00 | NPC1 (0.33) | NPC1RAB9AHSPA5MEN1KMT2A | |
| SCHEMBL7218372 | 0.80 | NOS1 (0.37) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28044670 | 0.76 | GSR (0.43) | NPC1RAB9AKMT2ADPP7 | |
| SCHEMBL7611110 | 0.70 | NPY4R (0.43) | — | |
| SCHEMBL7172385 | 0.68 | NOS2 (0.50) | MEN1KMT2ADPP7 | |
| SCHEMBL7915399 | 0.68 | NOS2 (0.50) | MEN1KMT2ADPP7 | |
| SCHEMBL28612372 | 0.67 | NPC1 (0.46) | NPC1RAB9AHSPA5KMT2AKDM4E | |
| SCHEMBL11599997 | 0.67 | NPC1 (0.46) | NPC1RAB9AHSPA5KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7218895 | 0.67 | NOS2 (0.51) | MEN1KMT2ADPP7 | |
| SCHEMBL7227260 | 0.67 | DPP7 (0.42) | MEN1KMT2ADPP7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | claimed |
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |