Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.36 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222786 | 0.94 | NTRK1 (0.44) | NTRK1NTRK2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL7121020 | 0.94 | F2 (0.46) | NTRK1NTRK2SMN1; SMN2LMNAF2 | |
| SCHEMBL7216788 | 0.94 | KDM4E (0.39) | NTRK1NTRK2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL7219016 | 0.93 | CA12 (0.41) | NTRK1NTRK2LMNARAB9AKDM4E | |
| SCHEMBL7224671 | 0.91 | NTRK1 (0.40) | NTRK1NTRK2SMN1; SMN2LMNARAB9A | |
| SCHEMBL7216888 | 0.90 | F2 (0.37) | NTRK1NTRK2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL7223673 | 0.89 | F2 (0.39) | NTRK1NTRK2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL7118128 | 0.89 | F2 (0.49) | RAB9AKDM4ENPC1F2 | |
| SCHEMBL7114667 | 0.88 | F2 (0.45) | NTRK1NTRK2RAB9AKDM4ENPC1 | |
| SCHEMBL7120411 | 0.88 | F2 (0.46) | RAB9AKDM4ENPC1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656956-B2 | Tryptase inhibitor; antiinflamamtory agents, antiallergens | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-12-02 | — | — | US | disclosed |