Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218414 | 0.87 | SIRT6 (0.35) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7225467 | 0.85 | FOLH1 (0.35) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7226737 | 0.81 | FOLH1 (0.43) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7219144 | 0.79 | ANPEP (0.37) | CPB2 | |
| SCHEMBL7224448 | 0.74 | FOLH1 (0.37) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7218187 | 0.72 | — | — | |
| SCHEMBL7911902 | 0.70 | FOLH1 (0.40) | FOLH1SIRT1CPB2 | |
| SCHEMBL7911894 | 0.70 | FOLH1 (0.40) | FOLH1SIRT1CPB2 | |
| SCHEMBL7224658 | 0.68 | FOLH1 (0.46) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7224655 | 0.68 | FOLH1 (0.46) | FOLH1SIRT6SIRT1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |