Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226737 | 0.83 | FOLH1 (0.43) | FOLH1SIRT6SIRT1CPB2SLC6A5 | |
| SCHEMBL7225467 | 0.82 | FOLH1 (0.35) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7218414 | 0.76 | SIRT6 (0.35) | FOLH1SIRT6SIRT1CPB2SLC6A5 | |
| SCHEMBL7219614 | 0.74 | FOLH1 (0.33) | FOLH1SIRT6SIRT1CPB2 | |
| SCHEMBL7219144 | 0.69 | ANPEP (0.37) | CPB2TLR2KLKB1 | |
| SCHEMBL4902767 | 0.69 | SIRT1 (0.40) | FOLH1SIRT6SIRT1CPB2SLC6A5 | |
| SCHEMBL31243301 | 0.69 | TGFBR1 (0.44) | FOLH1SIRT6SIRT1CPB2SLC6A5 | |
| SCHEMBL28085656 | 0.69 | FOLH1 (0.47) | FOLH1SIRT6SIRT1CPB2SLC6A5 | |
| SCHEMBL2387748 | 0.67 | SIRT6 (0.54) | FOLH1SIRT6SIRT1ERAP2ERAP1 | |
| SCHEMBL5494276 | 0.67 | SIRT6 (0.54) | FOLH1SIRT6SIRT1ERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |