Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214195 | 0.78 | ALDH1A1 (0.42) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL3665175 | 0.75 | ALDH1A1 (0.40) | KDM4ERAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2828050 | 0.75 | KDM4E (0.54) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7220336 | 0.74 | POLB (0.62) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2905044 | 0.73 | SMN1; SMN2 (0.38) | KDM4ERAB9AKMT2AL3MBTL1TSHR | |
| SCHEMBL3120588 | 0.73 | ALDH1A1 (0.39) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8896304 | 0.72 | CYP1A2 (0.43) | KMT2A | |
| SCHEMBL7214682 | 0.72 | ALDH1A1 (0.56) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7214686 | 0.72 | ALDH1A1 (0.56) | KDM4ERAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7214687 | 0.72 | ALDH1A1 (0.56) | KDM4ERAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1124822-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |