Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25387815 | 0.84 | RET (0.56) | GPR119RETDDB1CRBN | |
| SCHEMBL21876057 | 0.84 | MAPT (0.62) | MAPTALDH1A1LMNAESR2NAMPT | |
| SCHEMBL18234283 | 0.83 | JAK2 (0.46) | — | |
| SCHEMBL13261275 | 0.83 | GPR119 (0.53) | MAPTGPR119RET | |
| SCHEMBL5573222 | 0.81 | MAPT (0.76) | MAPTALDH1A1LMNANAMPTGPR119 | |
| SCHEMBL1199807 | 0.81 | MAPT (0.58) | MAPTALDH1A1LMNAESR2NAMPT | |
| SCHEMBL5335367 | 0.81 | SMARCA2 (0.53) | MAPTALDH1A1LMNANAMPTGPR119 | |
| SCHEMBL4424363 | 0.79 | MAPT (0.60) | MAPTALDH1A1LMNAESR2NAMPT | |
| SCHEMBL4943581 | 0.79 | MAPT (0.56) | MAPTALDH1A1LMNANAMPTGPR119 | |
| SCHEMBL27025951 | 0.78 | MAPT (0.58) | MAPTALDH1A1LMNAESR2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589953-B2 | Treatment of anxiety, depression, aggressiveness, panic attacks, obsessive-compulsive disorders, schizophrenia, suicidal tendency, neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease | PIERRE FABRE MEDICAMENT (FR) | 2003-07-08 | — | — | US | disclosed |
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | PEREZ MICHEL (FR) | 2002-05-23 | — | — | US | disclosed |
| US-6277853-B1 | FOR TREATMENT OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MIGRAINES, ALCOHOLISM | PIERRE FABRE MEDICAMENT (FR) | 2001-08-21 | — | — | US | disclosed |
| CN-1272108-A | Indole derivatives useful as 5-HT 1B and 5-HIT 1D agonists | PF MEDICAMENT (FR) | 2000-11-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020061891-A1 | Indole derivatives as 5-HT1B and 5-HT1D agonists | HTR1B, HTR1A, HTR1D | MAPT 3195/4885ALDH1A1 358/4885LMNA 4076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.