SCHEMBL7219957

SCHEMBL7219957

COC(=O)C(C)c1cc(C)[c]c(C)c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MT-CO2 P00403 1/20 0.45
PTGS1 P23219 1/20 0.45
PTGS2 P35354 1/20 0.45
HPGD P15428 1/20 0.39
KMT2A Q03164 2/20 0.37
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TAS1R3 Q7RTX0 2/20 0.34
TAS1R1 Q7RTX1 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
TSHR P16473 1/20 0.34
RECQL P46063 1/20 0.34
MAOB P27338 1/20 0.33
PSEN1 P49768 1/20 0.32
PSEN2 P49810 1/20 0.32
APH1B Q8WW43 1/20 0.32
NCSTN Q92542 1/20 0.32
APH1A Q96BI3 1/20 0.32
PSENEN Q9NZ42 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7219204 0.83 TSHR (0.37) HPGDKMT2ATDP1SMN1; SMN2TSHR
SCHEMBL7690032 0.83 L3MBTL1 (0.47) MT-CO2PTGS1PTGS2TDP1L3MBTL1
SCHEMBL7687112 0.80 APP (0.44) MT-CO2KMT2AL3MBTL1
SCHEMBL8960078 0.80 MT-CO2 (0.47) MT-CO2PTGS1PTGS2HPGDKMT2A
SCHEMBL8960086 0.80 MT-CO2 (0.47) MT-CO2PTGS1PTGS2HPGDKMT2A
SCHEMBL7678302 0.78 MAPT (0.38) PTGS2TDP1L3MBTL1TSHR
SCHEMBL14264293 0.77 MT-CO2 (0.56) MT-CO2PTGS1PTGS2HPGDKMT2A
SCHEMBL5050127 0.76 MT-CO2 (0.47) MT-CO2PTGS1PTGS2HPGDKMT2A
SCHEMBL24132878 0.76 MT-CO2 (0.48) MT-CO2PTGS1PTGS2HPGDKMT2A
SCHEMBL25940541 0.74 PTGS1 (0.46) MT-CO2PTGS1PTGS2HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6495681-B1 PRODUCING LOCAL ANESTHESIA OF LONG-DURATION. THE COMPOUNDS OF THIS INVENTION ARE MULTIBINDING COMPOUNDS THAT COMPRISE FROM 2 TO 10 LIGANDS COVALENTLY ATTACHED TO A LINKER OR LINKERS, EACH LIGAND BEING CAPABLE OF BINDING TO A LIGAND BINDING SITE THERAVANCE INC. 2002-12-17 US claimed
US-6337423-B1 BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY ADVANCED MEDICINE, INC. 2002-01-08 US claimed
US-6576791-B1 Local anesthetic compounds and uses THERAVANCE, INC. 2003-06-10 US disclosed
US-6462034-B1 MULTIBINDING COMPOUNDS CONTAINING A SYMETRICAL DIAMINOTETRA-ETHERDODECANE RING WITH TWO SECONDARY AMIDE AND ADDITIONAL SUBSTITUENTS; VOLTAGE GATED SODIUM CHANNEL MODULATORS; LONG DURATION THERAVANCE, INC. 2002-10-08 US disclosed
US-6337423-B1 BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY ADVANCED MEDICINE, INC. 2002-01-08 US disclosed