SCHEMBL7219964

SCHEMBL7219964

CC(Oc1cc(COc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)ccc1Cl)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 17/20 0.45
MRGPRX4 Q96LA9 2/20 0.37
PPOX P50336 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227600 0.94 MRGPRX4 (0.39) PPARGMRGPRX4PPOX
SCHEMBL7227776 0.94 PPARG (0.39) PPARGMRGPRX4PPOX
SCHEMBL7227955 0.94 PPARG (0.39) PPARGMRGPRX4PPOX
SCHEMBL7226396 0.93 PPARG (0.38) PPARGMRGPRX4PPOX
SCHEMBL7220894 0.92 TSHR (0.38) PPARGMRGPRX4PPOX
SCHEMBL7225862 0.91 PPARG (0.37) PPARGMRGPRX4PPOX
SCHEMBL7227640 0.90 MRGPRX4 (0.39) PPARGMRGPRX4PPOX
SCHEMBL7220014 0.89 PPARG (0.38) PPARGPPOX
SCHEMBL7719036 0.89 PPOX (0.40) PPARGPPOX
SCHEMBL2149762 0.89 PPOX (0.40) PPARGPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6664214-B1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-16 US disclosed