SCHEMBL7227640

SCHEMBL7227640

CC(Oc1cccc(COc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)c1)C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 9/20 0.39
PTGDR2 Q9Y5Y4 1/20 0.38
PPOX P50336 3/20 0.38
DHODH Q02127 3/20 0.37
PPARG P37231 4/20 0.36
PPARA Q07869 2/20 0.36
CYP2C9 P11712 1/20 0.36
EGFR P00533 1/20 0.36
CHRM4 P08173 1/20 0.36
ADRB1 P08588 1/20 0.36
ADRA2A P08913 1/20 0.36
ALOX5 P09917 1/20 0.36
ADRB3 P13945 1/20 0.36
DRD2 P14416 1/20 0.36
ADRA2B P18089 1/20 0.36
CHRM3 P20309 1/20 0.36
TACR2 P21452 1/20 0.36
DRD1 P21728 1/20 0.36
TBXA2R P21731 1/20 0.36
SLC6A2 P23975 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7225614 0.92 MRGPRX4 (0.38) MRGPRX4PPOXDHODH
SCHEMBL7225862 0.92 PPARG (0.37) MRGPRX4PPOXDHODHPPARGPPARA
SCHEMBL7227600 0.90 MRGPRX4 (0.39) MRGPRX4PPOXDHODHPPARGPPARA
SCHEMBL7219964 0.90 PPARG (0.45) MRGPRX4PPOXPPARG
SCHEMBL7219980 0.89 FFAR1 (0.40) MRGPRX4PTGDR2PPOX
SCHEMBL7227776 0.88 PPARG (0.39) MRGPRX4PPOXPPARGPPARA
SCHEMBL7227955 0.88 PPARG (0.39) MRGPRX4PPOXDHODHPPARGPPARA
SCHEMBL7220894 0.88 TSHR (0.38) MRGPRX4PPOXPPARGPPARAHTR2B
SCHEMBL7219701 0.88 PPARG (0.38) PPOXDHODHPPARG
SCHEMBL7227026 0.88 DHODH (0.34) PPOXDHODHPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6664214-B1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-16 US disclosed