SCHEMBL7220067

SCHEMBL7220067

CCCc1cncc(CCC)c1C#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.39
RECQL P46063 1/20 0.39
ALDH1A1 P00352 8/20 0.35
HPGD P15428 6/20 0.35
HSD17B10 Q99714 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2E1 P05181 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2A6 P11509 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2B6 P20813 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDM4E B2RXH2 6/20 0.33
MAPT P10636 4/20 0.33
GAA P10253 3/20 0.33
HTT P42858 3/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
LMNA P02545 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7215525 0.88 ALDH1A1 (0.41) MAPK1RECQLALDH1A1HPGDHSD17B10
SCHEMBL7219732 0.82 CCNC (0.39) MAPK1ALDH1A1HPGDHSD17B10CYP1A2
SCHEMBL7220043 0.76 CYP2E1 (0.37) CYP2E1CYP2C8CYP2D6CYP2A6CYP2C9
SCHEMBL28229460 0.76 ALDH1A1 (0.40) MAPK1RECQLALDH1A1HPGDHSD17B10
SCHEMBL28654378 0.75 ALDH1A1 (0.39) MAPK1RECQLALDH1A1HPGDHSD17B10
SCHEMBL7215639 0.74 MAPK1 (0.40) MAPK1RECQLALDH1A1HPGDHSD17B10
SCHEMBL7213436 0.72 CYP2E1 (0.47) ALDH1A1HPGDCYP1A2CYP2E1CYP2C8
SCHEMBL20637525 0.70 PRKCI (0.38) ALDH1A1CYP2E1CYP2C8CYP2D6CYP2A6
SCHEMBL27645048 0.70 CYP2E1 (0.37) MAPK1RECQLCYP1A2CYP2E1CYP2C8
SCHEMBL16959558 0.68 S1PR1 (0.46) ALDH1A1HPGDKDM4EMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6603007-B1 Intermediates in the fields of pharmaceuticals, agrichemicals, ligands, silver halide photosensitive materials, liquid crystals, surfactants, electrophotography and organic electroluminescence SANKIO CHEMICAL CO., LTD. (JP) 2003-08-05 US disclosed
EP-1231207-A1 NOVEL BIPYRIDYL DERIVATIVES Sankio Chemical Co., Ltd. (JP) 2002-08-14 EP disclosed