SCHEMBL7220083

SCHEMBL7220083

CC(Oc1ccc(C(C)Oc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)cc1)C(=O)O

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.34
DHODH Q02127 13/20 0.34
PPOX P50336 3/20 0.33
PDK2 Q15119 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227626 0.91 PTGDR2 (0.35) PPARGDHODHPPOXPDK2PTGDR2
SCHEMBL7220338 0.90 PPOX (0.35) PPARGDHODHPPOXPTGDR2
SCHEMBL7226544 0.90 PPOX (0.33) PPARGDHODHPPOXPTGDR2
SCHEMBL7719036 0.89 PPOX (0.40) PPARGDHODHPPOXPTGDR2
SCHEMBL4572159 0.89 PPOX (0.40) PPARGDHODHPPOXPTGDR2
SCHEMBL2149762 0.89 PPOX (0.40) PPARGDHODHPPOXPTGDR2
SCHEMBL7225862 0.87 PPARG (0.37) PPARGDHODHPPOX
SCHEMBL7227026 0.84 DHODH (0.34) PPARGDHODHPPOX
SCHEMBL7219701 0.84 PPARG (0.38) PPARGDHODHPPOX
SCHEMBL7221822 0.84 DHODH (0.37) DHODHPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6664214-B1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-16 US disclosed