SCHEMBL4572159

SCHEMBL4572159

C[C@@H](Oc1cc(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PPOX P50336 4/20 0.40
PPARG P37231 3/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
DHODH Q02127 7/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.34
TSHR P16473 1/20 0.34
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7719036 1.00 PPOX (0.40) PPOXPPARGKDM4EALDH1A1HSD17B10
SCHEMBL2149762 1.00 PPOX (0.40) PPOXPPARGKDM4EALDH1A1HSD17B10
SCHEMBL7782676 0.92 PPOX (0.40) PPOXDHODH
SCHEMBL7258166 0.91 PPOX (0.39) PPOXDHODH
SCHEMBL3240495 0.91 BCAT1 (0.38) PPOXPPARGDHODH
SCHEMBL3828837 0.91 PPOX (0.36) PPOXDHODH
SCHEMBL12981626 0.90 PPOX (0.43) PPOXKDM4EALDH1A1DHODH
SCHEMBL7178022 0.90 PPOX (0.43) PPOXKDM4EALDH1A1DHODH
SCHEMBL7220083 0.89 PPARG (0.34) PPOXPPARGDHODHPTGDR2
SCHEMBL2838020 0.89 PPOX (0.36) PPOXPPARGDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2453018-B1 A herbicide metabolizing protein, a gene thereof and use thereof SUMITOMO CHEMICAL CO (JP) 2016-03-16 EP disclosed
US-8293979-B2 Weed controller metabolism proteins, genes, thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-23 US disclosed
US-8293979-B2 Weed controller metabolism proteins, genes, thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-23 US disclosed
EP-2453018-A1 A herbicide metabolizing protein, a gene thereof and use thereof Sumitomo Chemical Company, Limited (JP) 2012-05-16 EP disclosed
EP-1457558-B1 WEED CONTROLLER METABOLISM PROTEINS, GENES THEREOF AND USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-12-07 EP disclosed
US-20100313300-A1 WEED CONTROLLER METABOLISM PROTEINS, GENES, THEREOF AND USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED 2010-12-09 US disclosed
US-20100313300-A1 WEED CONTROLLER METABOLISM PROTEINS, GENES, THEREOF AND USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED 2010-12-09 US disclosed
US-7745699-B2 Weed controller metabolism proteins, genes thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US disclosed
US-7745699-B2 Weed controller metabolism proteins, genes thereof and use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-29 US disclosed
US-6391826-B1 HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-21 US disclosed
JP-2000319264-A OPTICALLY ACTIVE URACIL COMPOUND SUMITOMO CHEM CO LTD 2000-11-21 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100313300-A1 WEED CONTROLLER METABOLISM PROTEINS, GENES, THEREOF AND USE OF THE SAME HADHB, WEE1, AS3MT PPOX 583/4885PPARG 2080/4885KDM4E 1179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.