⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228353 | 0.76 | — | — | |
| SCHEMBL358262 | 0.76 | — | — | |
| SCHEMBL6641016 | 0.73 | KDM4E (0.39) | — | |
| SCHEMBL1904067 | 0.73 | L3MBTL1 (0.47) | — | |
| SCHEMBL574688 | 0.71 | — | — | |
| SCHEMBL16446647 | 0.71 | TRPM8 (0.35) | — | |
| SCHEMBL1751921 | 0.71 | — | — | |
| SCHEMBL574809 | 0.71 | — | — | |
| SCHEMBL7221398 | 0.70 | TP53 (0.36) | — | |
| SCHEMBL7653336 | 0.70 | KDM4D (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630485-B2 | For therapy of inflammatory disease | SYNTEX (U.S.A.) LLC | 2003-10-07 | — | — | US | disclosed |
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |