Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.31 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220437 | 0.82 | PTPN1 (0.40) | POLBATMADORA3ADORA2AADORA1 | |
| SCHEMBL7215256 | 0.78 | APEX1 (0.33) | ATMERN1APEX1 | |
| SCHEMBL14950486 | 0.72 | POLB (0.56) | POLBKDM4EHIF1A | |
| SCHEMBL10310217 | 0.72 | POLB (0.56) | POLBKDM4EHIF1A | |
| SCHEMBL10914209 | 0.71 | POLB (0.38) | POLBATMCYP1A1APEX1KDM4E | |
| SCHEMBL10918010 | 0.71 | ATM (0.46) | POLBATMCYP1A1MTNR1AMTNR1B | |
| SCHEMBL10920007 | 0.70 | ATM (0.39) | POLBATMCYP1A1APEX1KDM4E | |
| SCHEMBL10917251 | 0.70 | CYP1A1 (0.45) | POLBATMCYP1A1KDM4EHIF1A | |
| SCHEMBL10916878 | 0.70 | KDM4E (0.40) | POLBATMCYP1A1KDM4EHIF1A | |
| SCHEMBL10919523 | 0.69 | POLB (0.37) | POLBATMCYP1A1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576766-B1 | Competitive binding of phosphotyrosine-containing protein; veterinary medicine | ARIAD PHARMACEUTICALS, INC. | 2003-06-10 | — | — | US | disclosed |
| EP-1064289-A1 | HETEROCYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047529-A1 | HETEROCYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 1999-09-23 | — | — | WO | disclosed |