Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220509 | 1.00 | CRHR1 (0.40) | CRHR1CDK1CCNB1SMN1; SMN2MEN1 | |
| SCHEMBL7220506 | 1.00 | CRHR1 (0.40) | CRHR1CDK1CCNB1SMN1; SMN2MEN1 | |
| SCHEMBL7226449 | 0.92 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7226448 | 0.92 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7226443 | 0.92 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7220430 | 0.82 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL7220428 | 0.82 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL7222459 | 0.82 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL7222448 | 0.79 | GABRG2 (0.34) | CRHR1CDK1 | |
| SCHEMBL7222445 | 0.79 | GABRG2 (0.34) | CRHR1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | claimed |
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | disclosed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | disclosed |