Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24065910 | 0.98 | POLB (0.37) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL7255531 | 0.98 | POLB (0.37) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL8760475 | 0.87 | TDP1 (0.39) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL7260249 | 0.83 | KDM4E (0.35) | POLBKMT2AMAPTKDM4ELMNA | |
| SCHEMBL8157644 | 0.81 | TDP1 (0.42) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL1771995 | 0.81 | TDP1 (0.41) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL5356481 | 0.79 | TDP1 (0.45) | POLBTDP1KMT2AMEN1MAPT | |
| SCHEMBL29098818 | 0.76 | THRB (0.41) | — | |
| SCHEMBL24065904 | 0.76 | THRB (0.41) | — | |
| SCHEMBL15920997 | 0.75 | TDP1 (0.38) | POLBTDP1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552069-B1 | Having anti-estrogenic activity; for use in therapy | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1241166-A1 | 3-METHYL-CHROMAN AND -THIOCHROMAN DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-09-18 | — | — | EP | disclosed |