Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6163245 | 0.84 | ENPP3 (0.55) | ENPP3MAPTSCN9AENPP1NPC1 | |
| SCHEMBL6167491 | 0.83 | MAPT (0.45) | ENPP3MAPTERCC5FEN1SCN9A | |
| SCHEMBL6162997 | 0.81 | MAPT (0.54) | ENPP3MAPTSCN9AENPP1MEN1 | |
| SCHEMBL27615906 | 0.79 | GRM5 (0.50) | ERCC5FEN1MEN1KMT2ANPC1 | |
| SCHEMBL27615980 | 0.77 | ERCC5 (0.53) | MAPTERCC5FEN1MEN1KMT2A | |
| SCHEMBL27615894 | 0.76 | LDHA (0.46) | ERCC5FEN1GRM5 | |
| SCHEMBL27597132 | 0.76 | MAPT (0.53) | MAPTERCC5FEN1POLB | |
| SCHEMBL27597148 | 0.75 | ERCC5 (0.47) | MAPTERCC5FEN1MEN1KMT2A | |
| SCHEMBL27615888 | 0.75 | LARS1 (0.50) | MAPTERCC5FEN1MEN1KMT2A | |
| SCHEMBL14564372 | 0.75 | ENPP3 (0.71) | ENPP3SCN9ATP53POLBENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6544985-B2 | For therapy of acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits | HOFFMAN-LA ROCHE INC. | 2003-04-08 | — | — | US | disclosed |