Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 17/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223882 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1CYP2D6 | |
| SCHEMBL7228457 | 0.84 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL7228400 | 0.82 | ADORA2B (0.79) | ADORA2BADORA2AADORA3ADORA1CYP2C9 | |
| SCHEMBL7228404 | 0.82 | ADORA2B (0.79) | ADORA2BADORA2AADORA3ADORA1CYP2C9 | |
| SCHEMBL7220779 | 0.78 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1CYP2D6 | |
| SCHEMBL7220958 | 0.76 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL1223972 | 0.74 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1CYP2D6 | |
| SCHEMBL7220488 | 0.74 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1CYP2D6 | |
| SCHEMBL7222372 | 0.73 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1CYP2D6 | |
| SCHEMBL7227160 | 0.72 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545002-B1 | Treating asthma, diarrhea, insulin resistance, diabetes, ischemia/reprefusion injuries, diabetic retinopathy or hyperbaric oxygen-induced retinopathy | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2003-04-08 | — | — | US | disclosed |
| EP-1192158-A2 | SUBSTITUTED 8-PHENYLXANTHINES USEFUL AS ANTAGONISTS OF A 2B? ADENOSINE RECEPTORS | University of Virginia Patent Foundation (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000073307-A2 | SUBSTITUTED 8-PHENYLXANTHINES USEFUL AS ANTAGONISTS OF A2B ADENOSINE RECEPTORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2000-12-07 | — | — | WO | disclosed |