Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954227 | 0.80 | LIMK1 (0.58) | EGFRGPR3SRCGABRPGABRD | |
| SCHEMBL678690 | 0.77 | GPR3 (0.44) | EGFRGPR3GABRPGABRDGABRA1 | |
| SCHEMBL10548506 | 0.75 | UTS2R (0.52) | GPR3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6824799 | 0.73 | LIMK1 (0.67) | EGFRGPR3GABRPGABRDGABRA1 | |
| SCHEMBL29816091 | 0.71 | CSNK2A1 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23529370 | 0.71 | CSNK2A1 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10548732 | 0.71 | KDM4E (0.58) | GPR3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14193669 | 0.70 | SRC (0.50) | EGFRSRCMEN1NR2F2KMT2A | |
| SCHEMBL1609982 | 0.69 | GPR3 (0.52) | EGFRGPR3GABRPGABRDGABRA1 | |
| SCHEMBL30301791 | 0.68 | MAPT (0.51) | EGFRGPR3GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |