Sugi Predict

Sugi Predict / Compounds / Morpholine

Morpholine

Morpholine

SCHEMBL7222873

C1COCCN1.COC(=O)C1CN(C(C)=O)c2ccccc2CN1S(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 19/20 0.69
▸ MMP13 P45452 19/20 0.69
▸ ADAM17 P78536 19/20 0.69
▸ MMP9 P14780 17/20 0.69
▸ ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5657799 0.91 MMP1 (0.82) MMP1MMP13ADAM17MMP9ALDH1A1
Dimethylamine SCHEMBL6642543 0.89 MMP1 (0.79) MMP1MMP13ADAM17MMP9ALDH1A1
SCHEMBL6608003 0.84 MMP1 (0.61) MMP1MMP13ADAM17MMP9
SCHEMBL6647225 0.83 MMP1 (0.69) MMP1MMP13ADAM17MMP9ALDH1A1
SCHEMBL5655828 0.83 MMP1 (0.68) MMP1MMP13ADAM17MMP9ALDH1A1
SCHEMBL6614299 0.83 MMP1 (0.80) MMP1MMP13ADAM17MMP9
SCHEMBL7222869 0.82 MMP1 (0.71) MMP1MMP13ADAM17MMP9
Dimethylamine SCHEMBL7424112 0.82 MMP1 (0.79) MMP1MMP13ADAM17MMP9
SCHEMBL27547263 0.82 MMP1 (1.00) MMP1MMP13ADAM17MMP9
SCHEMBL5656287 0.81 MMP1 (0.83) MMP1MMP13ADAM17MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6544984-B1 Treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss. AMERICAN CYANAMID COMPANY 2003-04-08 — — US disclosed