Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.61 |
| ▸ | ARNT | P27540 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Firocoxib SCHEMBL1383179 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5140758 | 0.75 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL20289792 | 0.72 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL21273790 | 0.71 | PTGS2 (0.71) | PTGS2PTGS1BRD4 | |
| SCHEMBL15714003 | 0.70 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL14280452 | 0.69 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL17208127 | 0.68 | PTGS2 (0.77) | PTGS2PTGS1 | |
| SCHEMBL14315246 | 0.68 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL22808772 | 0.66 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL21816582 | 0.65 | PTGS2 (0.66) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541646-B2 | Reacting an oxirane compound containing phenylsulfonyl group with an acid in an anhydrous medium to form an intermediate, reacting the intermediate with a storng base in an aprotic solvent to form an ester compound,dehydrating the ester comp. | MERIAL (FR) | 2003-04-01 | — | — | US | disclosed |
| US-20030028036-A1 | Method of preparing COX-2 inhibitors | MERIAL (FR) | 2003-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030028036-A1 | Method of preparing COX-2 inhibitors | PTGS2, PTGS1, PTGES2 | PTGS2 1/4885PTGS1 2/4885ARNT 1182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.