Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339319 | 0.82 | ALDH1A1 (0.39) | NPC1ALDH1A1PLA2G1BNFKB1CASP3 | |
| SCHEMBL7300296 | 0.82 | ALDH1A1 (0.30) | ALDH1A1ACHE | |
| SCHEMBL720712 | 0.80 | ALDH1A1 (0.38) | NPC1ALDH1A1PLA2G1BNFKB1CASP3 | |
| SCHEMBL457843 | 0.80 | TSHR (0.39) | ALDH1A1MEN1KMT2AKIF11 | |
| SCHEMBL18242765 | 0.80 | TSHR (0.39) | — | |
| SCHEMBL18244108 | 0.77 | — | — | |
| SCHEMBL18242244 | 0.77 | PTPN1 (0.33) | — | |
| SCHEMBL2251521 | 0.74 | — | — | |
| SCHEMBL18241929 | 0.74 | — | — | |
| SCHEMBL18243528 | 0.74 | PTPN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759318-B2 | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections | INHIBITEX, INC. (US) | 2014-06-24 | — | — | US | claimed |
| US-20120052046-A1 | Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2012-03-01 | — | — | US | claimed |
| EP-2385951-A2 | PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS | University College Cardiff Consultants, Ltd. (GB) | 2011-11-16 | — | — | EP | claimed |
| US-20110254856-A1 | MOBILE TERMINAL AND METHOD OF CONTROLLING OPERATION OF THE MOBILE TERMINAL | LG ELECTRONICS INC. (KR) | 2011-10-20 | — | — | US | claimed |
| WO-2010081082-A2 | PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS | UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED (GB) | 2010-07-15 | — | — | WO | claimed |
| US-8759318-B2 | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections | INHIBITEX, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20120052046-A1 | Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
| EP-2385951-A2 | PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS | University College Cardiff Consultants, Ltd. (GB) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254856-A1 | MOBILE TERMINAL AND METHOD OF CONTROLLING OPERATION OF THE MOBILE TERMINAL | LG ELECTRONICS INC. (KR) | 2011-10-20 | — | — | US | disclosed |
| WO-2010081082-A2 | PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS | UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED (GB) | 2010-07-15 | — | — | WO | disclosed |
| EP-0058839-B1 | SENSITIZED ORGANIC ELECTRON DONOR COMPOUNDS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1986-04-16 | — | — | EP | disclosed |
| EP-0058840-B1 | ELECTRON DONOR COMPOUNDS AND PHOTOCONDUCTIVE CHARGE TRANSPORT MATERIALS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4367274-A | Sensitized organic electron donor bis-benzocarbazole compounds | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4361637-A | Electron bis-benzocarbazole donor compounds and photoconductive charge transport materials | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-11-30 | — | — | US | disclosed |
| US-4357405-A | Fluorinated dye sensitized organic electron donor compound | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-11-02 | — | — | US | disclosed |
| US-4356244-A | Quinoxaline cyanine dye sensitized organic electron donor compounds | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-10-26 | — | — | US | disclosed |
| EP-0058840-A1 | Electron donor compounds and photoconductive charge transport materials | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-09-01 | — | — | EP | disclosed |
| EP-0058839-A1 | Sensitized organic electron donor compounds | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-09-01 | — | — | EP | disclosed |
| US-4337305-A | INDOLE CYANINE DYES HAVING PHENYLSULFONYL OR BENZOYL GROUPS; LIGHT SENSITIVE ELEMENTS; ELECTROGRAPHY | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052046-A1 | Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections | PNP, SAMHD1, MTAP | NPC1 927/4885ALDH1A1 4139/4885PLA2G1B 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.