Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233121 | 0.90 | USP30 (0.37) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7234821 | 0.90 | HDAC1 (0.43) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7235102 | 0.90 | USP30 (0.52) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7225108 | 0.89 | USP30 (0.43) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7233293 | 0.89 | USP30 (0.43) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7231008 | 0.88 | USP30 (0.43) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7225968 | 0.88 | USP30 (0.43) | CHRNB2CHRNA4USP30DGAT1GRM5 | |
| SCHEMBL7222621 | 0.88 | HDAC1 (0.46) | HDAC1HDAC6CHRNB2CHRNA4USP30 | |
| SCHEMBL7230675 | 0.85 | HDAC1 (0.49) | HDAC1HDAC6USP30DGAT1NPC1 | |
| SCHEMBL7224407 | 0.85 | USP30 (0.47) | CHRNB2CHRNA4USP30DGAT1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |