Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232208 | 0.91 | USP30 (0.46) | USP30CHEK1CTSCPAX8CHRNB2 | |
| SCHEMBL7235102 | 0.87 | USP30 (0.52) | USP30CHRNB2CHRNA4DGAT1 | |
| SCHEMBL7225108 | 0.86 | USP30 (0.43) | USP30HPGDSCHRNB2CHRNA4DGAT1 | |
| SCHEMBL7233293 | 0.86 | USP30 (0.43) | USP30CHEK1HPGDSCHRNB2CHRNA4 | |
| SCHEMBL7224140 | 0.85 | HDAC1 (0.47) | USP30CHEK1GRM5CHRNB2CHRNA4 | |
| SCHEMBL7231008 | 0.85 | USP30 (0.43) | USP30SLC6A2SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL7225968 | 0.85 | USP30 (0.43) | USP30CHEK1GRM5CHRNB2CHRNA4 | |
| SCHEMBL7222621 | 0.85 | HDAC1 (0.46) | USP30GRM5CHRNB2CHRNA4DGAT1 | |
| SCHEMBL7224885 | 0.85 | HPGDS (0.52) | CHEK1CTSCSLC6A2SLC6A3PAX8 | |
| SCHEMBL7224838 | 0.84 | USP30 (0.46) | USP30CHEK1CTSCSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |