Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233293 | 0.91 | USP30 (0.43) | USP30DGAT1HDAC6HDAC1CHRNB2 | |
| SCHEMBL7225108 | 0.91 | USP30 (0.43) | USP30DGAT1HDAC6HDAC1CHRNB2 | |
| SCHEMBL7232442 | 0.90 | USP30 (0.42) | USP30DGAT1KDRHDAC6HDAC1 | |
| SCHEMBL7224545 | 0.90 | USP30 (0.41) | USP30DGAT1HDAC6HDAC1 | |
| SCHEMBL7231136 | 0.90 | DGAT1 (0.41) | USP30DGAT1CHRNB2CHRNA4 | |
| SCHEMBL7225968 | 0.90 | USP30 (0.43) | USP30DGAT1CHRNB2CHRNA4 | |
| SCHEMBL7231008 | 0.90 | USP30 (0.43) | USP30DGAT1HDAC6HDAC1CHRNB2 | |
| SCHEMBL7224140 | 0.90 | HDAC1 (0.47) | USP30DGAT1HDAC6HDAC1CHRNB2 | |
| SCHEMBL7222621 | 0.90 | HDAC1 (0.46) | USP30DGAT1HDAC6HDAC1CHRNA7 | |
| SCHEMBL7232956 | 0.89 | DGAT1 (0.41) | USP30DGAT1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |