Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574268 | 0.90 | PDPK1 (0.46) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7226278 | 0.89 | AURKA (0.49) | MAPTPDPK1KMT2AMEN1AURKA | |
| SCHEMBL7226273 | 0.88 | LRRK2 (0.48) | MAPTNPC1RAB9ALRRK2PDPK1 | |
| SCHEMBL1954821 | 0.88 | KMT2A (0.47) | NPC1RAB9APDPK1KMT2AMEN1 | |
| SCHEMBL12550480 | 0.88 | KMT2A (0.47) | NPC1RAB9APDPK1KMT2AMEN1 | |
| SCHEMBL1954823 | 0.88 | KMT2A (0.47) | NPC1RAB9APDPK1KMT2AMEN1 | |
| SCHEMBL7972611 | 0.88 | KMT2A (0.47) | NPC1RAB9APDPK1KMT2AMEN1 | |
| SCHEMBL7984532 | 0.87 | RAB9A (0.49) | MAPTNPC1RAB9ALRRK2PSEN1 | |
| SCHEMBL7226408 | 0.86 | LRRK2 (0.47) | MAPTNPC1RAB9ALRRK2PDPK1 | |
| SCHEMBL7226405 | 0.86 | LRRK2 (0.47) | MAPTNPC1RAB9ALRRK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |