Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 4/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.33 |
| ▸ | HTR3B | O95264 | 4/20 | 0.33 |
| ▸ | HTR3A | P46098 | 4/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233633 | 0.87 | ITK (0.39) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7225620 | 0.85 | AKT1 (0.37) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7224622 | 0.84 | CHRNA7 (0.37) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7232161 | 0.83 | CHRNA7 (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7226769 | 0.83 | SLC6A3 (0.31) | — | |
| SCHEMBL7232339 | 0.83 | CHRNA7 (0.36) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7225220 | 0.83 | CHRNA7 (0.39) | CHRNA7KDM4ENPC1MAPTHPGD | |
| SCHEMBL7225334 | 0.83 | SLC6A3 (0.32) | — | |
| SCHEMBL7232602 | 0.82 | CHRNA7 (0.38) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7224906 | 0.81 | CHRNA7 (0.38) | CHRNA7AKT1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |