Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.31 |
| ▸ | SELE | P16581 | 2/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225406 | 0.91 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7226063 | 0.90 | SLC6A3 (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7232894 | 0.90 | SLC6A4 (0.38) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL7232164 | 0.90 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL7223713 | 0.90 | CHRNA7 (0.34) | ITK | |
| SCHEMBL7226487 | 0.89 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3CNR1 | |
| SCHEMBL7225137 | 0.88 | GRM5 (0.35) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL7224609 | 0.88 | CRBN (0.34) | SLC6A2SLC6A4SLC6A3ITK | |
| SCHEMBL7115100 | 0.86 | CHRNA7 (0.36) | SLC6A2SLC6A4SLC6A3ITK | |
| SCHEMBL7122496 | 0.85 | CHRNA7 (0.35) | SLC6A2SLC6A4SLC6A3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |