Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 5/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225336 | 0.89 | GRM5 (0.34) | GRM5HCRTR1PIK3CA | |
| SCHEMBL7231547 | 0.89 | CHRNB2 (0.36) | GRM5HCRTR1 | |
| SCHEMBL7224375 | 0.88 | SLC6A2 (0.38) | ICAM1SELEITKKMT2AMEN1 | |
| SCHEMBL7223713 | 0.88 | CHRNA7 (0.34) | ITKUSP30 | |
| SCHEMBL7224292 | 0.88 | MAOA (0.38) | GRM5SYKHCRTR1PIK3CASLC6A2 | |
| SCHEMBL7231206 | 0.85 | HSD17B1 (0.37) | GRM5ICAM1SELEHCRTR1SLC6A2 | |
| SCHEMBL7225406 | 0.83 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7232139 | 0.83 | USP30 (0.32) | ICAM1SELESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7232164 | 0.82 | SLC6A2 (0.32) | KMT2AMEN1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7226063 | 0.82 | SLC6A3 (0.38) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |