Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.67 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.67 |
| ▸ | FYN | P06241 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224559 | 0.83 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7225665 | 0.82 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659147 | 0.81 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7231276 | 0.81 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7225939 | 0.78 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7226062 | 0.78 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7225937 | 0.78 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7232228 | 0.77 | GABRG2 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7233140 | 0.76 | GABRG2 (0.73) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7234152 | 0.76 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | claimed |
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | disclosed |