Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.45 |
| ▸ | HTR3B | O95264 | 4/20 | 0.45 |
| ▸ | HTR3A | P46098 | 4/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232261 | 0.90 | CHRNA7 (0.47) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7223923 | 0.89 | PTPN11 (0.49) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7224991 | 0.89 | ESRRG (0.46) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7230658 | 0.87 | CHRNA7 (0.46) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7231972 | 0.87 | ESRRG (0.46) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL375517 | 0.86 | CHRNA7 (0.57) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7223338 | 0.86 | CHRNA7 (0.57) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7224860 | 0.86 | KDM4E (0.55) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7232519 | 0.85 | MAPK11 (0.48) | PTPN1PTPN11CHRNA7HTR3EHTR3B | |
| SCHEMBL7224193 | 0.84 | HDAC3 (0.53) | PTPN1PTPN11CHRNA7HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |