Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375394 | 0.80 | NPC1 (0.44) | KDM4EALDH1A1LMNAL3MBTL1CHRNA4 | |
| SCHEMBL7074460 | 0.80 | NPC1 (0.44) | KDM4EALDH1A1LMNAL3MBTL1CHRNA4 | |
| SCHEMBL7230851 | 0.79 | CHRNA7 (0.35) | ALDH1A1LMNAHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL7075781 | 0.79 | NPC1 (0.43) | KDM4EALDH1A1LMNAL3MBTL1CHRNA4 | |
| SCHEMBL7225481 | 0.78 | NPSR1 (0.45) | ALDH1A1NPSR1MAPTMAPK1HTR3E | |
| SCHEMBL7077969 | 0.77 | HPGD (0.55) | KDM4EALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL7225387 | 0.76 | C3AR1 (0.44) | KDM4EALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL7231936 | 0.76 | KCNH2 (0.46) | KDM4EALDH1A1LMNAL3MBTL1CHRNA4 | |
| SCHEMBL7230640 | 0.76 | NPC1 (0.45) | KDM4EALDH1A1LMNAL3MBTL1NPSR1 | |
| Hydrochloric Acid SCHEMBL7074818 | 0.76 | HPGD (0.53) | KDM4EALDH1A1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |