Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225739 | 0.90 | ALDH1A1 (0.45) | NPSR1MAPTMAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7224670 | 0.90 | LMNA (0.43) | NPSR1MAPTMAPK1ALDH1A1SLC6A3 | |
| SCHEMBL7233832 | 0.87 | SLC6A3 (0.42) | NPSR1MAPTMAPK1ALDH1A1MMP13 | |
| SCHEMBL7226375 | 0.87 | MAPT (0.48) | NPSR1MAPTMAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7232058 | 0.86 | NPSR1 (0.40) | NPSR1MAPTMAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7230399 | 0.86 | MAPT (0.36) | NPSR1MAPTMAPK1ALDH1A1SLC6A4 | |
| SCHEMBL7225022 | 0.85 | NPC1 (0.42) | NPSR1MAPTMAPK1ALDH1A1HTR3E | |
| SCHEMBL7125195 | 0.84 | MMP2 (0.36) | NPSR1ALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL7232127 | 0.83 | SLC9A1 (0.48) | MAPTMAPK1ALDH1A1HTR3EHTR3B | |
| SCHEMBL7233162 | 0.83 | HTR3E (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |