Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 16/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908736 | 0.83 | FOLH1 (0.41) | FOLH1SIRT2SIRT1C3AR1 | |
| SCHEMBL7908742 | 0.83 | FOLH1 (0.41) | FOLH1SIRT2SIRT1C3AR1 | |
| SCHEMBL7219493 | 0.82 | FOLH1 (0.43) | FOLH1CD274 | |
| SCHEMBL7220594 | 0.80 | FOLH1 (0.41) | FOLH1 | |
| SCHEMBL7218185 | 0.80 | FOLH1 (0.39) | FOLH1CD274SIRT2SIRT1 | |
| SCHEMBL7224733 | 0.78 | TDP1 (0.36) | TDP1 | |
| SCHEMBL7908794 | 0.74 | C3AR1 (0.41) | FOLH1C3AR1 | |
| SCHEMBL27675504 | 0.73 | NAAA (0.56) | TDP1 | |
| SCHEMBL7225509 | 0.72 | MMP2 (0.44) | FOLH1C3AR1 | |
| SCHEMBL7225506 | 0.72 | MMP2 (0.44) | FOLH1C3AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |