⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8687 | 0.97 | — | — | |
| SCHEMBL40550 | 0.87 | — | — | |
| SCHEMBL18975256 | 0.84 | HSD17B10 (0.50) | — | |
| SCHEMBL130493 | 0.84 | HSD17B10 (0.50) | — | |
| SCHEMBL2335615 | 0.84 | HSD17B10 (0.50) | — | |
| SCHEMBL23014949 | 0.84 | HSD17B10 (0.50) | — | |
| SCHEMBL8907249 | 0.84 | HSD17B10 (0.50) | — | |
| SCHEMBL130671 | 0.84 | — | — | |
| SCHEMBL23014965 | 0.84 | HSD17B10 (0.50) | — | |
| Hydrochloric Acid SCHEMBL5806207 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562963-B2 | Coupling using organosilicon compound | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-20020013459-A1 | Process for the preparation of macrocyclic metalloprotease inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-01-31 | — | — | US | disclosed |
| US-6307044-B1 | Process for the preparation of macrocyclic metalloprotease inhibitors | DUPONT PHARMACEUTICALS COMPANY | 2001-10-23 | — | — | US | disclosed |
| EP-1084113-A1 | A PROCESS FOR THE PREPARATION OF MACROCYCLIC METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999064406-A1 | A PROCESS FOR THE PREPARATION OF MACROCYCLIC METALLOPROTEASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |