Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225141 | 0.89 | USP30 (0.44) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7233259 | 0.89 | HDAC3 (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7224996 | 0.88 | USP30 (0.42) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7232029 | 0.87 | HDAC1 (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7226045 | 0.87 | USP30 (0.43) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7223371 | 0.87 | USP30 (0.42) | HDAC1USP30GSK3BPTPN1 | |
| SCHEMBL7231198 | 0.87 | SMN1; SMN2 (0.47) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7234180 | 0.87 | USP30 (0.42) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7226143 | 0.87 | PTPN11 (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7071274 | 0.86 | USP30 (0.53) | HDAC1HDAC6USP30PPARAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |